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Introducing an Evidence-to-Impact Framework

Writer: Maren Fragala
Maren Fragala
Jul 27
2 min read

Updated: Jul 28

Why do so many scientific discoveries fail to achieve their full patient-impact potential?


The greatest limitation in science is often not discovery. It is implementation.

After years of working across academia, diagnostics, sports science, medical affairs, and population health management, we have seen the size of the evidence-to-practice gap—and how much scientific value and patient impact can be lost within it.


Healthcare may be able to learn something from sports science.


Sports scientists are expert translators. They study how the body functions and adapts—but their work does not end with publication. The evidence must be translated into practical decisions that coaches and athletes can understand, adopt, and apply to improve performance. Leading sports science journals reinforce this expectation by asking researchers to explain the practical applications of their findings.


Healthcare needs the same commitment to scientific translation.

Scientific discovery and evidence generation are only the beginning. Moving from evidence to measurable healthcare impact requires:


  • Evidence that addresses real-world stakeholder needs

  • Strategy that anticipates barriers to adoption• Translation of complex science into clear, actionable insights

  • Communication tailored to clinicians, payers, health systems, executives, and patients

  • Implementation that integrates evidence into practice

  • Measurement of clinical, economic, and patient outcomes


That thinking inspired the SciSquared Evidence-to-Impact Framework—a clear way to demonstrate how science creates value by moving from:


DISCOVERY → EVIDENCE → STRATEGY → TRANSLATION → COMMUNICATION → ADOPTION → PATIENT IMPACT


At SciSquared, we built our scientific agency to help fill this implementation gap.


We combine scientific rigor, strategic insight, and visual communication to transform complex clinical and real-world evidence into content stakeholders can understand, trust, and use.


Our services span medical and scientific writing, evidence strategy, publication planning, scientific advisory, executive and stakeholder summaries, publication extenders, infographics, and scientific visualization—all designed to support better decisions, greater adoption, and measurable impact.


Because the true value of a scientific discovery is not simply that it is published.


It is that it reaches the people it was meant to help.


This is the first in a series exploring how we can better connect evidence generation with real-world healthcare outcomes.


Where is the implementation gap in your organization—and what would become possible if you filled it?


Learn more: www.scisquared.com Start a conversation: info@scisquared.com


 
 
 

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